电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

Recombinant IgE 抗体

适用: 人 ELISA, BR 宿主: 兔 Chimeric TES-C21 unconjugated Recombinant Antibody
产品编号 ABIN7072337
发货至: 中国
  • 抗原 See all IgE 抗体
    IgE
    抗体类型
    Recombinant Antibody
    适用
    • 19
    • 2
    • 2
    • 1
    宿主
    • 14
    • 8
    • 1
    • 1
    克隆类型
    • 18
    • 6
    Chimeric
    标记
    • 17
    • 3
    • 2
    • 1
    • 1
    This IgE antibody is un-conjugated
    应用范围
    • 13
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Blocking Reagent (BR)
    原理
    Anti-IgE [TES-C21], Rabbit IgG, kappa
    产品特性

    Original Species of Ab: Mouse

    Original Format of Ab: IgG

    纯化方法
    Protein A affinity purified
    免疫原
    Polyclonal human IgE.
    克隆位点
    TES-C21
    亚型
    IgG kappa
    Top Product
    Discover our top product IgE Primary Antibody
  • 应用备注
    The antibody binds specifically to IgE, an immunoglobulin isotype secreted by upon stimulation of B cells by interleukins Il-4 and IL-13. IgE provides immunity to parasites such as helminths and Plasmodium falciparum. The immunoglobulin also plays a central role in the development of Type I hypersensitivity reactions and allergic diseases such as asthma, sinusitis and food allergies. These allergic responses are triggered by the binding of IgE to the high affinity receptor FcεRI, expressed on the surface of basophils and mast cells. Binding of IgE causes cross-linking of the receptor, inducing degranulation and release of inflammatory mediators, particularly of histamine. The monoclonal antibody TES-C21 binds to secreted IgE and to IgE expressed on the surface of IgE-producing B cells, thereby inhibiting IgE binding to FcεRI and the release of histamine from mast cells. The monoclonal antibody can have diagnostic applications, such as for identifying and quantifying IgE-expressing B cells and IgE levels in serum samples, and therapeutic applications in the treatment of allergies. Furthermore, the antibody can conjugated to cytotoxic drugs and deliver them specifically to IgE-producing B cells.
    说明

    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % Proclin 300.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原
    IgE
    Abstract
    IgE 产品
    背景
    Immunoglobulin E
You are here:
客服