Recombinant BACE2 抗体
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- 抗原 See all BACE2 抗体
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- 抗体类型
- Recombinant Antibody
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This BACE2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- Anti-BACE2 [1/ 9 ], Mouse IgG1, kappa
- 产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG
- 纯化方法
- Protein A affinity purified
- 免疫原
- Human BACE2 244-333.
- 克隆位点
- 1-9
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product BACE2 Primary Antibody
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anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 230-396) antibody
BACE2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 242-502) antibodyBACE2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 240-470) antibodyBACE2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 156-407) antibodyBACE2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 84-157) antibodyBACE2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 44-59) antibodyBACE2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 336-365) antibodyBACE2 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 101-200) antibodyBACE2 适用: 大鼠 ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 306-395) antibodyBACE2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 71-120) antibodyBACE2 适用: 人, 大鼠, 小鼠, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.
- 说明
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This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- 别名
- BACE2 (BACE2 产品)
- 背景
- Beta-secretase 2, Aspartic-like protease, Aspartyl protease 1, Asp1, Beta-site amyloid precursor protein cleaving enzyme 2, Down syndrome aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, theta-secretase
- UniProt
- Q9Y5Z0
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