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GRAP2 抗体 (APC)

GRAP2 适用: 人 FACS 宿主: 小鼠 Monoclonal UW40 APC
产品编号 ABIN7013927
发货至: 中国
  • 抗原 See all GRAP2 抗体
    GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This GRAP2 antibody is conjugated to APC
    应用范围
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    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
    纯化方法
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    GST-fusion human GRAP2/GADS protein
    克隆位点
    UW40
    亚型
    IgG2a
    Top Product
    Discover our top product GRAP2 Primary Antibody
  • 应用备注
    Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • 抗原
    GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
    别名
    GRAP2 (GRAP2 产品)
    别名
    GADS antibody, GRAP-2 antibody, GRB2L antibody, GRBLG antibody, GRID antibody, GRPL antibody, GrbX antibody, Grf40 antibody, Mona antibody, P38 antibody, Gads antibody, GrpL antibody, zgc:112091 antibody, GRAP2 antibody, grap2 antibody, zgc:65942 antibody, GRB2-related adaptor protein 2 antibody, GRB2-related adaptor protein 2a antibody, GRB2-related adaptor protein 2b antibody, GRAP2 antibody, Grap2 antibody, grap2a antibody, grap2 antibody, grap2b antibody
    背景
    GRB2 related adaptor protein 2,GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.,GADS, GRID, GRAP-2, GrbX
    基因ID
    9402
    UniProt
    O75791
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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