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MAP3K8 抗体 (AA 121-220)

Name: MAP3K8 抗体 (AA 121-220)
SKU: ABIN701275
Availability: OutOfStock

MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-MAP3K8/TPL2 Polyclonal Antibody, Unconjugated (ABIN701275) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (MAP3K8 抗体 (AA 121-220))

IHC

Lane 1: rat brain lysates Lane 2: rat heart lysates probed with Anti MAP3K8/TPL2 Polyclonal Antibody, Unconjugated (ABIN701275) at 1:200 in 4 °C. (MAP3K8 抗体 (AA 121-220))

SDS

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-MAP3K8/TPL2 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining. (MAP3K8 抗体 (AA 121-220))

IHC (p)

Formalin-fixed and paraffin embedded mouse lymphoma labeled with Rabbit Anti MAP3K8/TPL2 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (MAP3K8 抗体 (AA 121-220))

IHC (p)

Formalin-fixed and paraffin embedded mouse lymphoma labeled with Rabbit Anti MAP3K8/TPL2 Polyclonal Antibody, Unconjugated (ABIN701275) at 1:200 followed by conjugation to the secondary antibody and DAB staining (MAP3K8 抗体 (AA 121-220))

IHC

5 images

产品编号 ABIN701275

发货至: 中国

Datasheet as PDF

抗原 See all MAP3K8 抗体

MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
抗原表位
19

12

9

8

7

5

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 121-220
适用
86

40

38

7

4

4

4

2

2

1

1
人, 大鼠, 小鼠
宿主
85

1
兔
Compatible Secondaries
克隆类型
85

1
多克隆
标记
37

8

7

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This MAP3K8 antibody is un-conjugated
应用范围
54

39

29

16

8

7

3

3

2

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Cow,Horse,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human MAP3K8

亚型

IgG
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 1-300) antibody
MAP3K8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pThr290) antibody
MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) antibody
MAP3K8 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 256-305) antibody
MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (Ser400) antibody
MAP3K8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 368-397), (C-Term) antibody
MAP3K8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB03467 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pSer290) antibody
MAP3K8 适用: 人, 大鼠, 小鼠, Cow, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pSer400) antibody
MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pThr290) antibody
MAP3K8 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pThr290) antibody
MAP3K8 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

别名

MAP3K8 (MAP3K8 产品)

别名

MAP3K8 antibody, COT antibody, EST antibody, ESTF antibody, MEKK8 antibody, TPL2 antibody, Tpl-2 antibody, c-COT antibody, Cot antibody, Cot/Tpl2 antibody, Est antibody, Estf antibody, Tpl2 antibody, D17TPL2 antibody, mitogen-activated protein kinase kinase kinase 8 antibody, MAP3K8 antibody, map3k8 antibody, Map3k8 antibody

背景

Synonyms: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT, Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, MAP3K8
Background: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

基因ID

1326

UniProt

P41279

途径

PI3K-Akt Signaling, TCR Signaling