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Phospholamban 抗体 (pThr17)

PLN 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7265288
发货至: 中国
  • 抗原 See all Phospholamban (PLN) 抗体
    Phospholamban (PLN)
    抗原表位
    • 25
    • 17
    • 11
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pThr17
    适用
    • 79
    • 19
    • 18
    • 3
    • 2
    • 2
    • 2
    人, 大鼠, 小鼠
    宿主
    • 79
    • 1
    • 1
    克隆类型
    • 79
    • 2
    多克隆
    标记
    • 34
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Phospholamban antibody is un-conjugated
    应用范围
    • 34
    • 26
    • 26
    • 26
    • 12
    • 10
    • 9
    • 9
    • 7
    • 6
    • 6
    • 4
    • 1
    • 1
    Immunohistochemistry (IHC)
    产品特性
    Phosphorylated antibody
    纯化方法
    Affinity purification
    免疫原
    A phospho specific peptide corresponding to residues surrounding T17 of human PLN
    亚型
    IgG
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    Discover our top product PLN Primary Antibody
  • 应用备注
    IHC 1:50-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Phospholamban (PLN)
    别名
    PLN (PLN 产品)
    背景
    The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
    基因ID
    5350
    UniProt
    P26678
    途径
    Negative Regulation of Transporter Activity
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