ESP1 antibody, SEPA antibody, mp:zf637-3-001691 antibody, AL024103 antibody, AU045071 antibody, Cerp antibody, PRCE antibody, SSE antibody, extra spindle pole bodies like 1, separase antibody, extra spindle poles like 1 antibody, extra spindle pole bodies 1, separase antibody, ESPL1 antibody, espl1 antibody, Espl1 antibody
背景
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.