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SHC1 抗体
SHC1
适用: 人, 小鼠, 大鼠
IHC, IF
宿主: 兔
Polyclonal
unconjugated
SHC1抗体详情
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抗原
See all SHC1 抗体
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
适用
All reactivities for SHC1 抗体
人, 小鼠, 大鼠
宿主
All hosts for SHC1 抗体
兔
克隆类型
All clonalities for SHC1 抗体
多克隆
标记
All conjugates for SHC1 抗体
This SHC1 antibody is un-conjugated
应用范围
All applications for SHC1 抗体
Immunohistochemistry (IHC), Immunofluorescence (IF)
产品特性
Polyclonal Antibody
纯化方法
Affinity purification
免疫原
A synthetic peptide of human SHC1
亚型
IgG
Top Product
Discover our top product SHC1 Primary Antibody
Alternatives
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使用细节
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应用备注
IHC 1:50-1:200 IF 1:50-1:200
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
1 mg/mL
缓冲液
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Store at -20°C. Avoid freeze / thaw cycles.
SHC1目标详情
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抗原
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
别名
SHC1 (SHC1 产品 )
别名
SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
背景
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
基因ID
6464
UniProt
P29353
途径
RTK signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , ER-Nucleus Signaling , Signaling Events mediated by VEGFR1 and VEGFR2
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