AG2 antibody, GOB-4 antibody, HAG-2 antibody, PDIA17 antibody, XAG-2 antibody, Agr2h antibody, Gob-4 antibody, mAG-2 antibody, wu:fj29g05 antibody, zgc:112187 antibody, agr2 antibody, hag3 antibody, hag-3 antibody, bcmp11 antibody, MGC89004 antibody, XAgr2 antibody, agr2-A antibody, anterior gradient 2, protein disulphide isomerase family member antibody, anterior gradient 2 antibody, anterior gradient 3, protein disulphide isomerase family member antibody, anterior gradient 2, protein disulphide isomerase family member S homeolog antibody, AGR2 antibody, Agr2 antibody, agr2 antibody, agr3 antibody, agr2.S antibody
背景
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.