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- 抗原 See all AF4 (AFF1) products
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AF4 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of human AFF1 (NP_001160165.1).
- 亚型
- IgG
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anti-AF4/FMR2 Family, Member 1 (AFF1) (AA 1181-1210) antibody
AFF1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (N-Term) antibodyAFF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (AA 1-183) antibodyAFF1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF 1:50-1:100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
- 别名
- AFF1 (AFF1 产品)
- 别名
- AF4 antibody, MLLT2 antibody, PBM1 antibody, 9630032B01Rik antibody, AW319193 antibody, Af4 antibody, Mllt2h antibody, Rob antibody, Mllt2 antibody, AF4/FMR2 family member 1 antibody, AF4/FMR2 family, member 1 antibody, AFF1 antibody, Aff1 antibody
- 背景
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
- 基因ID
- 4299
- UniProt
- P51825
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