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ROBO3 抗体

ROBO3 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7261161
发货至: 中国
  • 抗原 See all ROBO3 抗体
    ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
    适用
    • 21
    • 4
    • 3
    • 3
    • 3
    • 1
    小鼠
    宿主
    • 15
    • 4
    • 4
    克隆类型
    • 21
    • 2
    多克隆
    标记
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ROBO3 antibody is un-conjugated
    应用范围
    • 14
    • 13
    • 5
    • 1
    Western Blotting (WB)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein of human ROBO3 (NP_071765.2).
    亚型
    IgG
    Top Product
    Discover our top product ROBO3 Primary Antibody
  • 应用备注
    WB 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
    别名
    ROBO3 (ROBO3 产品)
    别名
    HGPPS antibody, HGPS antibody, RBIG1 antibody, RIG1 antibody, CG14345 antibody, CT17158 antibody, Robo-3 antibody, Robo3 antibody, dRobo-3 antibody, DmelCG5423 antibody, CG5423 antibody, ROBO3 antibody, robo3 antibody, DKFZp468G0223 antibody, Rbig1 antibody, Rig-1 antibody, Rig1 antibody, Robo3a antibody, Robo3b antibody, cb503 antibody, roundabout guidance receptor 3 antibody, roundabout 3 antibody, robo3 antibody, roundabout guidance receptor 3 L homeolog antibody, roundabout, axon guidance receptor, homolog 3 (Drosophila) antibody, ROBO3 antibody, robo3 antibody, Robo3 antibody, LOC658818 antibody, robo3.L antibody
    背景
    This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
    分子量

    Observed_MW: 200 kDa

    Calculated_MW: 110 kDa/148 kDa

    基因ID
    64221
    UniProt
    Q96MS0
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