EB1 antibody, 5530600P05Rik antibody, AI462499 antibody, AI504412 antibody, AW260097 antibody, BIM1p antibody, D2Ertd459e antibody, Eb1 antibody, MAPRE1 antibody, mapre1l antibody, wu:fi33c06 antibody, zgc:55428 antibody, zgc:77807 antibody, mapre1 antibody, wu:fa01e12 antibody, wu:fc23e11 antibody, zgc:85755 antibody, MGC52508 antibody, eb1 antibody, xEB1B antibody, Mapre3 antibody, microtubule associated protein RP/EB family member 1 antibody, microtubule-associated protein, RP/EB family, member 1 antibody, microtubule-associated protein, RP/EB family, member 1a antibody, microtubule-associated protein, RP/EB family, member 1b antibody, microtubule associated protein RP/EB family member 1 L homeolog antibody, microtubule associated protein RP/EB family member 1 S homeolog antibody, MAPRE1 antibody, Mapre1 antibody, mapre1a antibody, mapre1b antibody, mapre1.L antibody, mapre1.S antibody
背景
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.