HLA-DQA1 抗体
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- 抗原 See all HLA-DQA1 抗体
- HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DQA1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of human HLA-DQA1 (NP_002113.2).
- 亚型
- IgG
- Top Product
- Discover our top product HLA-DQA1 Primary Antibody
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- 应用备注
- WB 1:500-1:2000 IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))
- 别名
- HLA-DQA1 (HLA-DQA1 产品)
- 别名
- CD antibody, CELIAC1 antibody, DQ-A1 antibody, GSE antibody, HLA-DQA antibody, BoLA-DQA antibody, hla-dqa1 antibody, major histocompatibility complex, class II, DQ alpha 1 antibody, major histocompatibility complex, class II, DQ alpha, type 1 antibody, major histocompatibility complex, class II, DQ alpha 1 L homeolog antibody, HLA-DQA1 antibody, BOLA-DQA1 antibody, hla-dqa1.L antibody
- 背景
- HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
- 分子量
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Observed_MW: 28 kDa-37KD
Calculated_MW: 27 kDa
- 基因ID
- 3117
- UniProt
- P01909
- 途径
- TCR Signaling, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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