NUAK1 抗体
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- 抗原 See all NUAK1 抗体
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NUAK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of human NUAK1 (NP_055655.1).
- 亚型
- IgG
- Top Product
- Discover our top product NUAK1 Primary Antibody
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- 应用备注
- WB 1:200-1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
- 别名
- NUAK1 (NUAK1 产品)
- 别名
- ARK5 antibody, AU014801 antibody, AW494241 antibody, B230104P22Rik antibody, Omphk1 antibody, NUAK family kinase 1 antibody, NUAK family, SNF1-like kinase, 1 antibody, NUAK1 antibody, Nuak1 antibody
- 背景
- NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
- 分子量
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Observed_MW: 74 kDa
Calculated_MW: 23 kDa/74 kDa
- 基因ID
- 9891
- UniProt
- O60285
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