ZBTB33 抗体
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- 抗原 See all ZBTB33 抗体
- ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZBTB33 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of human ZBTB33 (NP_006768.1).
- 亚型
- IgG
- Top Product
- Discover our top product ZBTB33 Primary Antibody
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- 应用备注
- WB 1:1000-1:3000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))
- 别名
- ZBTB33 (ZBTB33 产品)
- 别名
- kaiso antibody, ZNF-kaiso antibody, ZNF348 antibody, AW260253 antibody, E130014G12Rik antibody, Kaiso antibody, Znf-kaiso antibody, RGD1566309 antibody, zinc finger and BTB domain containing 33 S homeolog antibody, zinc finger and BTB domain containing 33 antibody, zbtb33.S antibody, ZBTB33 antibody, Zbtb33 antibody
- 背景
- This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
- 分子量
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Observed_MW: 74 kDa
Calculated_MW: 74 kDa
- 基因ID
- 10009
- UniProt
- Q86T24
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