DNAJA1 antibody, dj-2 antibody, dja1 antibody, hdj-2 antibody, hdj2 antibody, hsdj antibody, hsj2 antibody, hspf4 antibody, nedd7 antibody, Hsj2 antibody, Nedd7 antibody, DJ-2 antibody, DjA1 antibody, HDJ2 antibody, HSDJ antibody, HSJ2 antibody, HSPF4 antibody, NEDD7 antibody, hDJ-2 antibody, dnaja1l antibody, dnj-12 antibody, wu:fc14c09 antibody, zgc:55650 antibody, dnaJ homolog subfamily A member 1 pseudogene antibody, DnaJ heat shock protein family (Hsp40) member A1 antibody, DnaJ heat shock protein family (Hsp40) member A1 L homeolog antibody, DnaJ (Hsp40) homolog, subfamily A, member 1 antibody, LOC703360 antibody, dnaja1 antibody, DNAJA1 antibody, dnaja1.L antibody, Dnaja1 antibody
背景
This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes.