CHD4 antibody, im:7143343 antibody, si:ch211-51m24.3 antibody, si:ch211-57k11.10 antibody, wu:fb44b12 antibody, wu:fd12d03 antibody, MGC145363 antibody, Mi-2b antibody, Mi2-BETA antibody, Mi-2 antibody, 9530019N15Rik antibody, AA617397 antibody, BC005710 antibody, D6Ertd380e antibody, Mi-2beta antibody, mKIAA4075 antibody, b230399n07 antibody, chromodomain helicase DNA binding protein 4 antibody, chromodomain helicase DNA binding protein 4a antibody, chromodomain helicase DNA binding protein 4b antibody, chromodomain helicase DNA binding protein 4 L homeolog antibody, CHD4 antibody, chd4a antibody, chd4b antibody, chd4 antibody, Chd4 antibody, chd4.L antibody
背景
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.