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- 抗原 See all SETDB1 抗体
- SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SETDB1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Antigen affinity purification
- 免疫原
- Fusion protein of human SETDB1
- 亚型
- IgG
- Top Product
- Discover our top product SETDB1 Primary Antibody
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anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibody
SETDB1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A3 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) antibodySETDB1 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 5H6A12 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) antibodySETDB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5H6D4 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1058-1075) antibodySETDB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225) antibodySETDB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibodySETDB1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225), (C-Term) antibodySETDB1 适用: 人 WB 宿主: 兔 Polyclonal RB5748 unconjugated
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- 应用备注
- IHC 1:50-1:300, ELISA 1:5000-1:10000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.08 mg/mL
- 缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
- 别名
- SETDB1 (SETDB1 产品)
- 背景
- SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
- UniProt
- Q15047
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