Myogenin 抗体
-
- 抗原 See all Myogenin (MYOG) 抗体
- Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
-
适用
- 人, 小鼠, 大鼠, Pig, Cow, 小鸡
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This Myogenin antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- Cow, 人, 小鼠, 大鼠
- 预测反应
- Pig
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human MYOG/Myogenin
- 亚型
- IgG
- Top Product
- Discover our top product MYOG Primary Antibody
-
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 4-219) antibody
MYOG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-224) antibodyMYOG 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2B7 unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-224) antibodyMYOG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-224) antibodyMYOG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-224) antibodyMYOG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E19 unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-1) antibodyMYOG 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-30) antibodyMYOG 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (Internal Region) antibodyMYOG 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (Internal Region) antibodyMYOG 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myogenin (Myogenic Factor 4) (MYOG) (AA 1-224) antibodyMYOG 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3E3 unconjugated
-
- 应用备注
-
WB(1:100-500)
Optimal working dilution should be determined by the investigator. - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
-
- 抗原
- Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
- 别名
- Myogenin (MYOG 产品)
- 背景
-
Synonyms: MYF4, myf-4, bHLHc3, Myogenin, Class C basic helix-loop-helix protein 3, Myogenic factor 4, MYOG
Background: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth, phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
- 分子量
- 25kDa
- 基因ID
- 4656
- UniProt
- P15173
- 途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
-
