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FKBPL 抗体

FKBPL 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7252003
发货至: 中国
  • 抗原 See all FKBPL 抗体
    FKBPL (FK506 Binding Protein Like (FKBPL))
    适用
    • 42
    • 14
    • 13
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 39
    • 4
    克隆类型
    • 40
    • 3
    多克隆
    标记
    • 22
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This FKBPL antibody is un-conjugated
    应用范围
    • 18
    • 13
    • 13
    • 12
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 1
    Immunohistochemistry (IHC), ELISA
    产品特性
    Polyclonal Antibody
    纯化方法
    Antigen affinity purification
    免疫原
    Fusion protein of human FKBPL
    亚型
    IgG
    Top Product
    Discover our top product FKBPL Primary Antibody
  • 应用备注
    IHC 1:30-1:150, ELISA 1:2000-1:10000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.3 mg/mL
    缓冲液
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    FKBPL (FK506 Binding Protein Like (FKBPL))
    别名
    FKBPL (FKBPL 产品)
    别名
    FKBPL antibody, ng7 antibody, dir1 antibody, wisp39 antibody, DIR1 antibody, NG7 antibody, WISP39 antibody, Ppiase-X antibody, Wisp39 antibody, FK506 binding protein like antibody, FK506 binding protein-like antibody, FKBPL antibody, fkbpl antibody, Fkbpl antibody
    背景
    FKBPL,also named as DIR1,NG7 and WISp39,has similarity to the immunophilin protein family,which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance,probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant,whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 Molecular complexes, furthermore,FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.
    UniProt
    Q9UIM3
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