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- 抗原 See all JAK2 抗体
- JAK2 (Janus Kinase 2 (JAK2))
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适用
- 人, 大鼠, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This JAK2 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 产品特性
- Monoclonal Antibody
- 纯化方法
- Protein A purification
- 免疫原
- Synthetic Peptide of JAK2
- 克隆位点
- 3F10
- 亚型
- IgG
- Top Product
- Discover our top product JAK2 Primary Antibody
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anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人, 大鼠, 小鼠, 兔, 斑马鱼 WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 916-1103) antibodyJAK2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 745-955) antibodyJAK2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5C12C9 unconjugated
anti-Janus Kinase 2 (JAK2) (AA 508-800) antibodyJAK2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr931) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr221) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibodyJAK2 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 1A4 unconjugated Recombinant Antibody
anti-Janus Kinase 2 (JAK2) (C-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 1101-1132) antibodyJAK2 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (N-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IHC 1:50-300
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- JAK2 (Janus Kinase 2 (JAK2))
- 别名
- JAK2 (JAK2 产品)
- 背景
- Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- UniProt
- O60674
- 途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
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