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ATM 抗体
ATM
适用: 人, 小鼠, 大鼠
IHC (p)
宿主: 小鼠
Monoclonal
1D1
unconjugated
ATM抗体详情
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抗原
See all ATM 抗体
ATM
(Ataxia Telangiectasia Mutated (ATM))
适用
All reactivities for ATM 抗体
人, 小鼠, 大鼠
宿主
All hosts for ATM 抗体
小鼠
克隆类型
All clonalities for ATM 抗体
单克隆
标记
All conjugates for ATM 抗体
This ATM antibody is un-conjugated
应用范围
All applications for ATM 抗体
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
产品特性
Monoclonal Antibody
纯化方法
Protein A purification
免疫原
Recombinant Protein of ATM of ATM
克隆位点
1D1
亚型
IgG
Top Product
Discover our top product ATM Primary Antibody
Alternatives
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使用细节
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应用备注
IHC 1:100-200
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
1 mg/mL
缓冲液
PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Store at -20°C. Avoid freeze / thaw cycles.
ATM目标详情
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抗原
ATM
(Ataxia Telangiectasia Mutated (ATM))
别名
ATM (ATM 产品 )
别名
ATM antibody, Atm antibody, CG6535 antibody, Dmel\\CG6535 antibody, Tefu antibody, atm antibody, atm/tefu antibody, dATM antibody, tef antibody, Xatm antibody, at1 antibody, atdc antibody, tel1 antibody, telo1 antibody, AT1 antibody, ATA antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, TEL1 antibody, TELO1 antibody, AI256621 antibody, C030026E19Rik antibody, telomere fusion antibody, ATM serine/threonine kinase L homeolog antibody, ATM serine/threonine kinase antibody, ataxia telangiectasia mutated antibody, ataxia telangiectasia mutated (atm) antibody, serine/threonine-protein kinase ATM antibody, tefu antibody, atm.L antibody, atm antibody, ATM antibody, EDI_100660 antibody, CpipJ_CPIJ001772 antibody, BDBG_08252 antibody, PAAG_02532 antibody, MCYG_05088 antibody, VDBG_06833 antibody, ACLA_015700 antibody, LOC5565620 antibody, MGYG_07634 antibody, PGTG_14279 antibody, Atm antibody
背景
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
UniProt
Q13315
途径
p53 Pathway , Apoptosis , DNA Damage Repair , Inositol Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus
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