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SGK1 抗体

SGK1 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 小鼠 Monoclonal 4D12 unconjugated
产品编号 ABIN7250530
发货至: 中国
  • 抗原 See all SGK1 抗体
    SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))
    适用
    • 153
    • 97
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    • 7
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    • 4
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    • 1
    人, 小鼠, 大鼠
    宿主
    • 139
    • 10
    • 4
    • 1
    小鼠
    克隆类型
    • 144
    • 10
    单克隆
    标记
    • 61
    • 8
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    This SGK1 antibody is un-conjugated
    应用范围
    • 123
    • 50
    • 50
    • 43
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    • 28
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    • 21
    • 9
    • 6
    • 4
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    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    产品特性
    Monoclonal Antibody
    纯化方法
    Protein A purification
    免疫原
    Synthetic Peptide of SGK1
    克隆位点
    4D12
    亚型
    IgG
    Top Product
    Discover our top product SGK1 Primary Antibody
  • 应用备注
    IHC 1:100-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))
    别名
    SGK1 (SGK1 产品)
    背景
    Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
    UniProt
    O00141
    途径
    MAPK Pathway, Notch Signaling, Steroid Hormone Mediated Signaling Pathway
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