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beta Catenin 抗体

CATNB 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E4 unconjugated
产品编号 ABIN7250260
发货至: 中国
  • 抗原 See all beta Catenin (CATNB) 抗体
    beta Catenin (CATNB) (Catenin, beta (CATNB))
    适用
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    • 1
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    人, 小鼠, 大鼠
    宿主
    • 287
    • 56
    • 4
    • 1
    • 1
    小鼠
    克隆类型
    • 280
    • 69
    单克隆
    标记
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    This beta Catenin antibody is un-conjugated
    应用范围
    • 214
    • 159
    • 120
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    • 80
    • 64
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    • 51
    • 34
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    • 24
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    产品特性
    Monoclonal Antibody
    纯化方法
    Protein A purification
    免疫原
    Recombinant Protein
    克隆位点
    2E4
    亚型
    IgG
    Top Product
    Discover our top product CATNB Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    beta Catenin (CATNB) (Catenin, beta (CATNB))
    别名
    Catenin beta (CATNB 产品)
    别名
    Bfc antibody, Catnb antibody, Mesc antibody, CTNNB antibody, MRD19 antibody, armadillo antibody, ctnnb antibody, id:ibd2058 antibody, wu:fb73e10 antibody, wu:fi81c06 antibody, wu:fk25h01 antibody, beta-catenin antibody, ctnnb1 antibody, CHBCAT antibody, catenin (cadherin associated protein), beta 1 antibody, catenin beta 1 antibody, catenin (cadherin-associated protein), beta 1 antibody, catenin beta 1 L homeolog antibody, Ctnnb1 antibody, CTNNB1 antibody, ctnnb1 antibody, ctnnb1.L antibody
    背景
    Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
    分子量
    92 kDa
    UniProt
    P35222
    途径
    Peptide Hormone Metabolism
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