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Caspase 1 抗体

CASP1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7249876
发货至: 中国
  • 抗原 See all Caspase 1 (CASP1) 抗体
    Caspase 1 (CASP1)
    适用
    • 97
    • 34
    • 28
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 108
    • 10
    • 3
    • 1
    克隆类型
    • 100
    • 22
    多克隆
    标记
    • 80
    • 19
    • 8
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Caspase 1 antibody is un-conjugated
    应用范围
    • 95
    • 50
    • 48
    • 21
    • 14
    • 14
    • 12
    • 5
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein corresponding to Mouse Caspase1
    亚型
    IgG
    Top Product
    Discover our top product CASP1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:300-1:800
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.2 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Caspase 1 (CASP1)
    别名
    CASP1 (CASP1 产品)
    背景
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
    分子量

    Observed_MW: 45-47 kDa,30 kDa,35 kDa

    Calculated_MW: 45 kDa

    UniProt
    P29466, P29452, P43527
    途径
    Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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