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p130 抗体

RBL2 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7247960
发货至: 中国
  • 抗原 See all p130 (RBL2) 抗体
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    适用
    • 69
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    • 2
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    人, 大鼠, 小鼠
    宿主
    • 63
    • 7
    克隆类型
    • 64
    • 6
    多克隆
    标记
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    This p130 antibody is un-conjugated
    应用范围
    • 32
    • 27
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    • 1
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    ELISA, Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Antigen affinity purification
    免疫原
    Synthetic peptide of human RBL2
    亚型
    IgG
    Top Product
    Discover our top product RBL2 Primary Antibody
  • 应用备注
    IHC 1:30-1:150, ELISA 1:5000-1:10000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.8 mg/mL
    缓冲液
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    别名
    RBL2 (RBL2 产品)
    别名
    RBL2 antibody, RBR2 antibody, RRB2a antibody, PRB2 antibody, RBR-2 antibody, Rb2 antibody, p130 antibody, P130 antibody, retinoblastoma-like 2 (p130) antibody, RB transcriptional corepressor like 2 antibody, related to retinoblastoma 2 antibody, RBL2 antibody, LOC541652 antibody, Rbl2 antibody
    背景
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
    UniProt
    Q08999
    途径
    Cell Division Cycle, Mitotic G1-G1/S Phases
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