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Cullin 4A 抗体

CUL4A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7247885
发货至: 中国
  • 抗原 See all Cullin 4A (CUL4A) 抗体
    Cullin 4A (CUL4A)
    适用
    • 59
    • 27
    • 6
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    • 1
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    人, 小鼠
    宿主
    • 53
    • 6
    克隆类型
    • 47
    • 12
    多克隆
    标记
    • 31
    • 5
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    This Cullin 4A antibody is un-conjugated
    应用范围
    • 37
    • 24
    • 9
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    • 5
    • 4
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    • 2
    • 2
    • 1
    • 1
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Antigen affinity purification
    免疫原
    Synthetic peptide of human CUL4A
    亚型
    IgG
    Top Product
    Discover our top product CUL4A Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.62 mg/mL
    缓冲液
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Cullin 4A (CUL4A)
    别名
    CUL4A (CUL4A 产品)
    别名
    zgc:64071 antibody, CUL4A antibody, 2810470J21Rik antibody, AW495282 antibody, RGD1563853 antibody, cullin 4A antibody, CUL4A antibody, cul4a antibody, Cul4a antibody
    背景
    Cullin proteins assemble a large number of RING E3 ubiquitin ligases,participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins,CUL4A (87 kDa) and CUL4B(104 kDa),have been identified. The two CUL4 sequences are 83 % identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases,DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol,suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2.
    分子量

    Observed_MW: Refer to figures

    Calculated_MW: 88 kDa

    UniProt
    Q13619
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