FX antibody, P35B antibody, SDR4E1 antibody, AI256181 antibody, Tstap35b antibody, p35b antibody, sdr4e1 antibody, TSTA3 antibody, zgc:101805 antibody, si:dkey-235d18none antibody, Fx antibody, tissue specific transplantation antigen P35B antibody, tissue specific transplantation antigen P35B L homeolog antibody, TSTA3 antibody, Tsta3 antibody, tsta3 antibody, tsta3.L antibody
背景
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.