tmx3 antibody, pdia13 antibody, txndc10 antibody, txndc10a antibody, TXNDC10 antibody, zgc:110025 antibody, txndc10b antibody, DKFZp469P2316 antibody, PDIA13 antibody, 6430411B10Rik antibody, A730024F05Rik antibody, AV259382 antibody, Txndc10 antibody, mKIAA1830 antibody, thioredoxin-related transmembrane protein 3 S homeolog antibody, thioredoxin related transmembrane protein 3 antibody, thioredoxin related transmembrane protein 3a antibody, thioredoxin-related transmembrane protein 3 L homeolog antibody, thioredoxin-related transmembrane protein 3 antibody, tmx3.S antibody, TMX3 antibody, tmx3a antibody, tmx3.L antibody, tmx3 antibody, Tmx3 antibody
背景
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.