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- 抗原 See all C17ORF67 products
- C17ORF67 (Chromosome 17 Open Reading Frame 67 (C17ORF67))
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This C17ORF67 antibody is un-conjugated
- 应用范围
- ELISA, Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Antigen affinity purification
- 免疫原
- Fusion protein of human C17orf67
- 亚型
- IgG
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- 应用备注
- IHC 1:40-1:200, ELISA 1:5000-1:10000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.7 mg/mL
- 缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- C17ORF67 (Chromosome 17 Open Reading Frame 67 (C17ORF67))
- 别名
- C17orf67 (C17ORF67 产品)
- 别名
- chromosome 17 open reading frame 67 antibody, C17orf67 antibody
- 背景
- C17orf67 (chromosome 17 open reading frame 67) is a 114 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
- UniProt
- Q0P5P2
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