c12orf2 antibody, rassf8 antibody, wu:fb96e06 antibody, zgc:64017 antibody, C12orf2 antibody, HOJ1 antibody, 5133400D11Rik antibody, AA815821 antibody, AW123240 antibody, Hoj1 antibody, mHoj-1 antibody, RGD1308820 antibody, Ras association domain family member 8 antibody, Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b antibody, Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 antibody, RASSF8 antibody, rassf8b antibody, Rassf8 antibody
背景
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12,22)(p11.2,q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.