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NOG 抗体

NOG 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7244756
发货至: 中国
  • 抗原 See all NOG 抗体
    NOG (Noggin (NOG))
    适用
    • 60
    • 37
    • 29
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 79
    • 12
    • 1
    克隆类型
    • 82
    • 10
    多克隆
    标记
    • 36
    • 17
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This NOG antibody is un-conjugated
    应用范围
    • 73
    • 36
    • 23
    • 14
    • 13
    • 13
    • 9
    • 6
    • 6
    • 4
    • 3
    • 3
    • 1
    Immunohistochemistry (IHC), ELISA
    产品特性
    Polyclonal Antibody
    纯化方法
    Antigen affinity purification
    免疫原
    Synthetic peptide of human NOG
    亚型
    IgG
    Top Product
    Discover our top product NOG Primary Antibody
  • 应用备注
    IHC 1:25-1:100, ELISA 1:5000-1:10000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.9 mg/mL
    缓冲液
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    NOG (Noggin (NOG))
    别名
    NOG (NOG 产品)
    别名
    SYM1 antibody, SYNS1 antibody, nog-A antibody, nog1 antibody, noggin-1 antibody, noggin antibody, noggin antibody, noggin L homeolog antibody, noggin protein antibody, NOG antibody, Nog antibody, nog.L antibody, noggin antibody
    背景
    NOG (Noggin) is a Protein Coding gene. Diseases associated with NOG include Tarsal-Carpal Coalition Syndrome and Brachydactyly, Type B2. Among its related pathways are Mesodermal Commitment Pathway and Differentiation Pathway. GO annotations related to this gene include protein homodimerization activity and cytokine binding.The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified, both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene.
    UniProt
    Q13253
    途径
    Stem Cell Maintenance, Tube Formation
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