NAPI-1 antibody, NPT-1 antibody, NPT1 antibody, Napi-1 antibody, Napi1 antibody, Npt1 antibody, solute carrier family 17 member 1 antibody, solute carrier family 17 (sodium phosphate), member 1 antibody, SLC17A1 antibody, Slc17a1 antibody
背景
NPT1, also called sodium-dependent phosphate transport protein, belongs to the organic anion transporter family, SLC17A. It is mainly expressed in the kidney transporting small organic anions such as PAH (para-aminohippurate), but it is also found in the liver and brain. NTP1 localizes to the apical membrane of renal proximal tubular cells and functions as a voltage driven organic anion/Cl-exchanger. It also plays a role in maintaining phosphate homeostasis. The expression of NPT1 is transcriptionally regulated by HNF-1 and HNF-3. Indomethacin and salicylate inhibit NPT1-mediated PAH transport.