AI326936 antibody, Bp50 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, p50 antibody, Mpv17 antibody, Vip17 antibody, mal antibody, wyatt antibody, MALGENE antibody, im:7142606 antibody, zgc:112003 antibody, mal, T-cell differentiation protein antibody, CD40 antigen antibody, myelin and lymphocyte protein, T cell differentiation protein antibody, myelin and lymphocyte protein antibody, toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog antibody, MAL antibody, Cd40 antibody, Mal antibody, LOC100135389 antibody, mal antibody, tirap.L antibody
背景
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.