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POMC 抗体

POMC 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7242302
发货至: 中国
  • 抗原 See all POMC 抗体
    POMC (Proopiomelanocortin (POMC))
    适用
    • 59
    • 39
    • 36
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    • 1
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    人, 小鼠
    宿主
    • 48
    • 32
    • 1
    克隆类型
    • 48
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    多克隆
    标记
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    This POMC antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Synthetic peptide of human POMC
    亚型
    IgG
    Top Product
    Discover our top product POMC Primary Antibody
  • 应用备注
    WB 1:1000-1:5000, IHC 1:15-1:50
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.3 mg/mL
    缓冲液
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    POMC (Proopiomelanocortin (POMC))
    别名
    POMC (POMC 产品)
    别名
    MSH antibody, ACTH antibody, pomc antibody, SI:bZ36D5.1 antibody, SI:bZ36D5.4 antibody, si:bz36d5.2 antibody, BE antibody, Beta-LPH antibody, Clip antibody, Gamma-LPH antibody, Npp antibody, Pomc-1 antibody, Pomc1 antibody, alpha-MSH antibody, alphaMSH antibody, beta-MSH antibody, gamma-MSH antibody, CLIP antibody, LPH antibody, NPP antibody, POC antibody, Pomc2 antibody, proopiomelanocortin a antibody, pro-opiomelanocortin-alpha antibody, proopiomelanocortin antibody, pomca antibody, Pomc antibody, POMC antibody
    背景
    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
    分子量
    29 kDa
    NCBI登录号
    NP_000930
    UniProt
    P01189
    途径
    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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