VWA5A antibody, LOH11CR2A antibody, MGC68953 antibody, loh11cr2a antibody, BCSC-1 antibody, BCSC1 antibody, 5830475I06Rik antibody, AW552491 antibody, E130119J22 antibody, Loh11cr2a antibody, masa-1 antibody, loss of heterozygosity, 11, chromosomal region 2, gene A antibody, von Willebrand factor A domain containing 5A antibody, von Willebrand factor A domain containing 5A S homeolog antibody, LOH11CR2A antibody, VWA5A antibody, vwa5a.S antibody, vwa5a antibody, Vwa5a antibody
背景
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80 % of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.