ZMYND20 antibody, AI035571 antibody, Gna14 antibody, ankmy2 antibody, si:dkeyp-25a3.5 antibody, fi46e08 antibody, wu:fi46e08 antibody, zgc:55491 antibody, ankyrin repeat and MYND domain containing 2 antibody, ankyrin repeat and MYND domain containing 2b antibody, ankyrin repeat and MYND domain containing 2a antibody, ANKMY2 antibody, Ankmy2 antibody, ankmy2b antibody, ankmy2a antibody
背景
ANKMY2 (ankyrin repeat and MYND domain containing 2) is a 441 amino acid protein that contains three ANK repeats and one MYND-type zinc finger. Encoded by a gene that maps to human chromosome 7p21.1, ANKMY2 is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito and Caenorhabditis elegans. Downregulation of ANKMY2, associated with frequent deletions of human chromosome 7p22.1, indicate that ANKMY2 may role a role in the pathogenesis of natural killer (NK)-cell malignancies. ANKMY2 is also upregulated by enforced expression of Hox11, which functions broadly to hinder hemopoiesis, diverts differentiation to an alternative fate and promotes pre-leukaemic states.