1700058G18Rik antibody, 2900045G12Rik antibody, kcnmb4 antibody, potassium calcium-activated channel subfamily M regulatory beta subunit 4 antibody, potassium large conductance calcium-activated channel, subfamily M, beta member 4 antibody, potassium channel subfamily M regulatory beta subunit 4 antibody, Kcnmb4 antibody, KCNMB4 antibody, kcnmb4 antibody
背景
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.