ACSVL5 antibody, FATP antibody, FATP1 antibody, Fatp antibody, FATP-1 antibody, FATP-1c antibody, solute carrier family 27 member 1 antibody, solute carrier family 27 (fatty acid transporter), member 1 antibody, SLC27A1 antibody, Slc27a1 antibody
背景
The protein involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids .Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.