ARH6 antibody, ARHB antibody, MST081 antibody, MSTP081 antibody, RHOH6 antibody, AA017882 antibody, Arh6 antibody, Arhb antibody, RHO antibody, arha antibody, rhoa antibody, wu:fj42e08 antibody, zgc:92206 antibody, rhob antibody, xrhob antibody, ras homolog family member B antibody, ras homolog gene family, member Ab antibody, ras homolog family member B S homeolog antibody, RHOB antibody, Rhob antibody, rhoab antibody, rhob.S antibody
背景
Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.RHOB is a member of the Rho GTP-binding protein family.Mediates apoptosis in neoplastically transformed cells after DNA damage. It is not necessary for development but affects cell adhesion and growth factor signaling in transformed cells. It plays a negative role in tumorigenesis as deletion causes tumor formation. It involved in intracellular protein trafficking of a number of proteins, and serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.