NESHBP antibody, TARSH antibody, tarsh antibody, neshbp antibody, MGC107789 antibody, ABI3BP antibody, 5033411B22Rik antibody, AI506287 antibody, BG172926 antibody, D930038M13Rik antibody, eratin antibody, RGD1562717 antibody, ABI family member 3 binding protein antibody, ABI gene family, member 3 (NESH) binding protein antibody, ABI3BP antibody, abi3bp antibody, Abi3bp antibody
背景
A target of NESH-SH3/Abi3bp (TARSH) was originally identified as an SH3 domain-binding molecule of the NESH-SH3/Abi3 protein that is involved in Rac-dependent actin polymerization. In recent studies, TARSH gene expression was dramatically induced in mouse embryonic fibroblasts (MEFs) replicative senescence and suppressed in human lung carcinoma specimens and thyroid carcinomas. However, the molecular mechanism underlying the regulation of TARSH in tumorigenesis remains unclear.