ABCE1 antibody, DDBDRAFT_0188931 antibody, DDBDRAFT_0191227 antibody, DDB_0188931 antibody, DDB_0191227 antibody, abce1 antibody, MGC69546 antibody, DKFZp469K1416 antibody, ABC38 antibody, OABP antibody, RLI antibody, RNASEL1 antibody, RNASELI antibody, RNS4I antibody, C79080 antibody, Oabp antibody, RNS41 antibody, Rnaseli antibody, wu:fb34c09 antibody, wu:fe47b01 antibody, wu:fi09g07 antibody, zgc:111906 antibody, zgc:56045 antibody, Rns4i antibody, ATP binding cassette subfamily E member 1 antibody, 4Fe-4S ferredoxin, iron-sulfur binding domain-containing protein antibody, ATP-binding cassette sub-family E member 1 antibody, RNAse L inhibitor antibody, RNase L inhibitor antibody, ribosome biogenesis/translation initiation ATPase RLI antibody, ATP-binding cassette, sub-family E (OABP), member 1 antibody, ATP binding cassette subfamily E member 1 S homeolog antibody, ABCE1 antibody, abcE1 antibody, LOC100184673 antibody, LOC100213121 antibody, abce1 antibody, TP04_0855 antibody, PVX_115370 antibody, TERMP_RS03360 antibody, Abce1 antibody, abce1.S antibody
背景
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.