NFkB 抗体 (AA 805-892)
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- Key Features
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- High quality NFkB Primary Antibody for the detection of NFkB.
- Reliable product with high standard validation data
- 抗原 See all NFkB 抗体
- NFkB (Nuclear Factor kappa B (NFkB))
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抗原表位
- AA 805-892
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NFkB antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 原理
- Polyclonal Antibody to Nuclear Factor Kappa B (NFkB)
- 特异性
- The antibody is a rabbit polyclonal antibody raised against NFkB. It has been selected for its ability to recognize NFkB in immunohistochemical staining and western blotting.
- 交叉反应
- 小鼠, 大鼠
- 纯化方法
- Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- 免疫原
- Recombinant Nuclear Factor Kappa B (NFkB) corresdonding to Gln805~Ser892 (Accession # P19838) with N-terminal His and GST Tag
- 亚型
- IgG
- Top Product
- Discover our top product NFkB Primary Antibody
- Product Specific Information
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- What can the NFkB Antibody ABIN7442525 be used for?
- This polyclonal NFkB Antibody detects NFkB. The NFkB Antibody has been validated for various applications and can be used for the detection of NFkB and derivatives by Western Blotting, Immunohistochemistry, Immunoprecipitation, Immunocytochemistry.
- What validation data is available for this NFkB Antibody?
- The Primary Antibody has currently 6 product images that show its performance in a variety of applications. The product is currently available in 1 mL, 20 μL, 100 μL, 200 μL quantities. NFkB Antibody for the detection of NFkB and derivatives.
- What is the function of NFkB?
- This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
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- 应用备注
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Western blotting: 0.5-2 μg/mL
Immunohistochemistry: 5-20 μg/mL
Immunocytochemistry: 5-20 μg/mL
Optimal working dilutions must be determined by end user.
- 说明
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The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 0.01M PBS, pH 7.4, containing 0.05 % Proclin-300, 50 % glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
- 有效期
- 24 months
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- 抗原
- NFkB (Nuclear Factor kappa B (NFkB))
- 别名
- Nuclear Factor Kappa B (NFkB 产品)
- 别名
- EBP-1 antibody, KBF1 antibody, NF-kB1 antibody, NF-kappa-B antibody, NF-kappaB antibody, NFKB-p105 antibody, NFKB-p50 antibody, NFkappaB antibody, p105 antibody, p50 antibody, NF-kB antibody, NF-KB1 antibody, NF-kappaB1 antibody, p50/p105 antibody, nuclear factor kappa B subunit 1 antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 antibody, NFKB1 antibody, Nfkb1 antibody
- 背景
- NF-KB1, EBP-1, KBF1, NF-Kappa-B, NFKB-P105, NFKB-P50, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1, Nuclear factor NF-kappa-B p105 subunit
- 途径
- Ubiquitin Proteasome Pathway, S100 Proteins
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