SARS-CoV-2 ORF3a 抗体 (N-Term)
适用: SARS Coronavirus-2 (SARS-CoV-2)
ELISA, IHC
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all SARS-CoV-2 ORF3a products
- SARS-CoV-2 ORF3a
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抗原表位
- N-Term
- 适用
- SARS Coronavirus-2 (SARS-CoV-2)
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SARS-CoV-2 ORF3a antibody is un-conjugated
- 应用范围
- ELISA, Immunohistochemistry (IHC)
- 纯化方法
- SARS-CoV-2 (COVID-19) ORF3a Antibody is affinity chromatography purified via peptide column.
- 免疫原
- Anti-SARS-CoV-2 (COVID-19) ORF3a antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of SARS-CoV-2 (COVID-19) ORF3a protein. The immunogen is located within the first 50 amino acids of the SARS-CoV-2 (COVID-19) ORF3a protein.
- 亚型
- IgG
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anti-SARS-CoV-2 ORF3a (C-Term) antibody
适用: SARS Coronavirus-2 (SARS-CoV-2) WB 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- IHC: 0.2 μ,g/mL Antibody validated: Immunohistochemistry in human samples. Antibody validated: SARS-CoV-2 (COVID-19) ORF3a antibody can detect 2 ng of free peptide at 1 μ,g/mL in ELISA. All other applications and species not yet tested.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- SARS-CoV-2 (COVID-19) ORF3a antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- SARS-CoV-2 (COVID-19) ORF3a antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- SARS-CoV-2 ORF3a
- Abstract
- SARS-CoV-2 ORF3a 产品
- 别名
- ORF3a protein antibody, ORF3a antibody
- 物质类
- Viral Protein
- 背景
- Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. It up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. It induces apoptosis in cell culture and downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (3).
- 基因ID
- 43740569
- UniProt
- P0DTC3
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