C2CD3 antibody is affinity chromatography purified via peptide column.
免疫原
C2CD3 antibody was raised against an 18 amino acid peptide near the center of human C2CD3. The immunogen is located within amino acids 1490 - 1540 of C2CD3.
C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1). It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2,3). C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4,5).