SOX18 antibody is human, mouse and rat reactive. SOX18 is predicted to not cross-react with other SOX proteins.
纯化方法
SOX18 antibody is affinity chromatography purified via peptide column.
免疫原
SOX18 antibody was raised against a 17 amino acid peptide near the amino terminus of human SOX18. The immunogen is located within amino acids 40 - 90 of SOX18.
SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2). SOX18 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types (3). SOX is known to be involved with vascularization and endothelial development, suggesting that it may be useful as a potential target for inhibiting tumor angiogenesis (4). Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia (5).