Two isoforms of RRAS2 exists as a result of alternative splicing event.
纯化方法
RRAS2 Antibody is affinity chromatography purified via peptide column.
免疫原
Rabbit polyclonal RRAS2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human RRAS2. The immunogen is located within the last 50 amino acids of RRAS2.
TC21 antibody, 2610016H24Rik antibody, C86394 antibody, Ras-related protein R-Ras2 antibody, RAS related 2 antibody, related RAS viral (r-ras) oncogene 2 antibody, related RAS viral (r-ras) oncogene homolog 2 antibody, TVAG_453070 antibody, Bm1_46660 antibody, RRAS2 antibody, Rras2 antibody
背景
RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55-60 % . RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.