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PHLPP2 抗体 (C-Term)

PHLPP2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6991747
发货至: 中国
  • 抗原 See all PHLPP2 抗体
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    抗原表位
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    适用
    • 16
    • 5
    • 2
    • 1
    • 1
    宿主
    • 15
    • 1
    克隆类型
    • 16
    多克隆
    标记
    • 16
    This PHLPP2 antibody is un-conjugated
    应用范围
    • 15
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    At least three isoforms are known to exist, this antibody will detect the two largest isoforms. PHLPP2 antibody is predicted to not cross react with PHLPP1.
    纯化方法
    PHLPP2 Antibody is affinity chromatography purified via peptide column.
    免疫原
    PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2. The immunogen is located within the last 50 amino acids of PHLPP2.
    亚型
    IgG
    Top Product
    Discover our top product PHLPP2 Primary Antibody
  • 应用备注
    PHLPP2 antibody can be used for detection of PHLPP2 by Western blot at 1 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PHLPP2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,4 °C
    储存方法
    PHLPP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    别名
    PHLPP2 (PHLPP2 产品)
    别名
    PHLPPL antibody, phlppl antibody, AI481772 antibody, C130044A18Rik antibody, Phlppl antibody, RGD1562857 antibody, PH domain and leucine rich repeat protein phosphatase 2 antibody, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antibody, PHLPP2 antibody, phlpp2.S antibody, phlpp2 antibody, Phlpp2 antibody
    背景
    PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.
    分子量
    156 kDa
    基因ID
    23035
    NCBI登录号
    NP_055835
    UniProt
    Q6ZVD8
    途径
    PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway
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