GEMC1 抗体 (AA 130-180)
GMNC
适用: 人, 小鼠
WB, ELISA
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all GEMC1 (GMNC) 抗体
- GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))
- 抗原表位
- AA 130-180
- 适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GEMC1 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- GEMC1 Antibody is affinity chromatography purified via peptide column.
- 免疫原
- GEMC1 antibody was raised against a 19 amino acid synthetic peptide near the center of human GEMC1. The immunogen is located within amino acids 130 - 180 of GEMC1.
- 亚型
- IgG
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anti-Geminin Coiled-Coil Domain Containing (GMNC) (Center) antibody
GMNC 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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GEMC1 antibody can be used for detection of GEMC1 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- GEMC1 Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- GEMC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))
- 别名
- GEMC1 (GMNC 产品)
- 别名
- GEMC1 antibody, Gemc1 antibody, Gm1778 antibody, Gm606 antibody, gemc1 antibody, xGEMC1 antibody, geminin coiled-coil domain containing antibody, geminin coiled-coil domain containing S homeolog antibody, GMNC antibody, Gmnc antibody, gmnc.S antibody
- 背景
- GEMC1 Antibody: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
- 基因ID
- 647309
- NCBI登录号
- NP_001140158
- UniProt
- A6NCL1
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