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RWDD3 抗体 (C-Term)

RWDD3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6991193
发货至: 中国
  • 抗原 See all RWDD3 抗体
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    抗原表位
    • 12
    • 8
    • 3
    • 1
    • 1
    C-Term
    适用
    • 22
    • 7
    • 6
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 21
    • 1
    克隆类型
    • 22
    多克隆
    标记
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This RWDD3 antibody is un-conjugated
    应用范围
    • 21
    • 16
    • 15
    • 11
    • 2
    • 2
    Western Blotting (WB), ELISA
    纯化方法
    RWDD3 Antibody is affinity chromatography purified via peptide column.
    免疫原
    RWDD3 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RWDD3. The immunogen is located within the last 50 amino acids of RWDD3.
    亚型
    IgG
    Top Product
    Discover our top product RWDD3 Primary Antibody
  • 应用备注
    RWDD3 antibody can be used for detection of RWDD3 by Western blot at 1 μ,g/mL.

    Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    RWDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,4 °C
    储存方法
    RWDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    别名
    RWDD3 (RWDD3 产品)
    别名
    DKFZp469N1913 antibody, RSUME antibody, 2510027J23Rik antibody, 3110037C01Rik antibody, AI035684 antibody, AI662458 antibody, X2CR1 antibody, X2cr1 antibody, zgc:73229 antibody, RWD domain containing 3 antibody, RWDD3 antibody, rwdd3 antibody, Rwdd3 antibody
    背景
    RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ,Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α,-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ,Beta increased stability. RSUME-enhanced sumoylation of Iκ,Beta leads to the inhibition of NF-κ,Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
    基因ID
    25950
    NCBI登录号
    NP_056300
    UniProt
    Q9Y3V2
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