At least two isoforms of TOM70 are known to exist, this antibody will only detect the larger isoform.
纯化方法
TOM70 Antibody is affinity chromatography purified via peptide column.
免疫原
Anti-TOM70 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human TOM70. The immunogen is located within amino acids 50-100 of TOM70.
Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
TOM70 Antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
TOM70 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原
TOM70 (TOMM70A)
(Translocase of Outer Mitochondrial Membrane 70 (TOMM70A))
MGC68780 antibody, TOMM70A antibody, Tom70 antibody, KIAA0719 antibody, MGC73188 antibody, zgc:73188 antibody, wu:fj58b04 antibody, CG6756 antibody, Dmel\\CG6756 antibody, dtom70 antibody, GB13743 antibody, TOM70 antibody, 2610044B22Rik antibody, D16Ium22 antibody, D16Ium22e antibody, D16Wsu109e antibody, mKIAA0719 antibody, to translocase of outer mitochondrial membrane 70 S homeolog antibody, translocase of outer mitochondrial membrane 70 antibody, translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) antibody, Translocase of outer membrane 70 antibody, mitochondrial import receptor subunit TOM70 antibody, translocase of outer mitochondrial membrane 70 homolog A (yeast) antibody, tomm70.S antibody, TOMM70 antibody, tomm70a antibody, tomm70 antibody, Tom70 antibody, LOC726081 antibody, Tomm70 antibody, Tomm70a antibody
背景
TOM70 Antibody: The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear.